2017 Advanced Separation Science

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Academic unit or major
Graduate major in Chemistry
Okada Tetsuo  Fukuhara Gaku 
Class Format
Media-enhanced courses
Day/Period(Room No.)
Tue5-6(H111)  Fri5-6(H111)  
Course number
Academic year
Offered quarter
Syllabus updated
Lecture notes updated
Language used
Access Index

Course description and aims

This course teaches the fundamentals of separation required in various chemical studies. Molecular mechanisms that separation relies on, quantitative interpretation of separation processes, what causes good or poor separation etc will be theoretically considered based on physical phenomena including fluid mechanics and mass transfer as well as chemical interactions. This course enables students to overcome the problems that they will encounter in their own research work.

Student learning outcomes

By the end of this course, students will: 1. Know physics and chemistry involved in separation processes. 2. Understand the quantitative interpretation of results of separation. 3. Know dynamics and statics of separation processes. 4. Know how to improve separation performance. 5. Know that separation is not only a practical tool but also an efficient probe to the solution and interfacial phenomena


Two-phase distribution, Chromatography, Fluid mechanics, Electrostatic theory

Competencies that will be developed

Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Students should answer exercise quiz related to the lecture during each class.

Course schedule/Required learning

  Course schedule Required learning
Class 1 Molecular distribution in two phase systems Understand two phase distribution.
Class 2 Sequential partition Understand that sequential partition eventually gives Gaussian distribution.
Class 3 Fundamentals of chromatography Understand fundamentals of chromatography.
Class 4 Parameters in chromatographic separation Understand quantitative description of chromatography with physical and chemical parameters.
Class 5 Peak broadening Understand what causes peak broadening.
Class 6 Characteristics of fluid flow Understand fluid flow based on fluid mechanics.
Class 7 Diffusion and mass transport Understand diffusion and mass transport.
Class 8 Ion exchange Introduce concept of ion exchange.
Class 9 Electrostatic theory introduce electrostatic theory.
Class 10 Electrostatic interpretation of ion exchange Interpret ion exchange phenomena based on electrostatic theory.
Class 11 Secondary equilibrium chromatography enabling extraction of information on solution thermodynamics Understand effectiveness of secondary equilibrium chromatography as a tool for extraction of solution thermodynamic information.
Class 12 Electrohporesis Introduce principle of electrophoresis.
Class 13 Physical fields and their application to particle separation Introduce particle separation by the interaction with a physical field.



Reference books, course materials, etc.

Course materials are provided during class.

Assessment criteria and methods

Course scores are based on exercise quiz (100 %) .

Related courses

  • CHM.B331 : Quantitative Chemical Analysis
  • CHM.B202 : Basic Analytical Chemistry

Prerequisites (i.e., required knowledge, skills, courses, etc.)

No prerequisites are necessary, but enrollment in the related courses is desirable.

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