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2021　Organic Synthesis

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Academic unit or major
Undergraduate major in Chemistry
Instructor(s)
Ohmori Ken 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Tue3-4(H104)  Fri3-4(H104)  
Group
-
Course number
CHM.D331
Credits
2
Academic year
2021
Offered quarter
4Q
Syllabus updated
2021/3/19
Lecture notes updated
-
Language used
Japanese
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Course description and aims

This is a continuation of Organic Chemistry III. This course focuses on multistep synthesis of organic compounds, particularly introducing synthetic approaches to natural products.

Student learning outcomes

At the end of this course, students will be able to have an understanding of basic concept of retrosynthesis and to learn about various synthetic methodology en route to complex natural products.

Keywords

organic chemistry
synthetic organic chemistry
natural product synthesis
multi-step synthesis

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Every class will give exercises.

Course schedule/Required learning

  Course schedule Required learning
Class 1 History of organic synthesis and examples for chemical syntheses of complex molecules. Exercise problems might be given in this class.
Class 2 Concept of retro synthetic analysis I: latent polarity Exercise problems might be given in this class.
Class 3 Concept of retro synthetic analysis II: synthons Exercise problems might be given in this class.
Class 4 Formation of multiple C-C bonds, Wittig reaction, elimination Exercise problems might be given in this class.
Class 5 Formation of multiple C-C bonds, other methods Exercise problems might be given in this class.
Class 6 Synthesis of polycyclic compound: cyclization Exercise problems might be given in this class.
Class 7 Synthesis of polycyclic compound: annulation Exercise problems might be given in this class.
Class 8 Synthesis of chiral compound I: use of chiral synthons Exercise problems might be given in this class.
Class 9 Synthesis of chiral compound II: asymmetric reaction Exercise problems might be given in this class.
Class 10 Synthesis of alkaloids I: general approach Exercise problems might be given in this class.
Class 11 Synthesis of alkaloids II: construction of polycyclic skeleton Exercise problems might be given in this class.
Class 12 Synthesis of prostaglandins I: Corey lactone Exercise problems might be given in this class.
Class 13 Synthesis of prostaglandins II: other approaches Exercise problems might be given in this class.
Class 14 Exercise : basic and application problems Exercise problems might be given in this class.

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

None required

Reference books, course materials, etc.

None required

Assessment criteria and methods

Students’ course scores are based on final exams (ca. 70%), which will be held on site (not via online) and exercise problems and reports (ca. 30%).

Related courses

  • CHM.D201 ： Organic Chemistry I
  • CHM.D202 ： Organic Chemistry II
  • CHM.D301 ： Organic Chemistry III

Prerequisites (i.e., required knowledge, skills, courses, etc.)

Students require basic knowledge of organic chemistry.

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