I Natural products are relatively small molecules, produced mainly by plants and microorganisms, that have a long history of uses (and misuses) by people, e. g. poisons, antibiotics, perfumes, malodor ants, cosmetics, dietary supplements, etc.
II This course will focus on the basis of the biosynthetic pathways that lead to these natural organic compounds.
After successful completion of this course, students should be able to (1) understand the field of natural products chemistry;
(2) identify natural products and their probable biosynthetic pathways; (3) enhance their understanding of biological and biochemical sciences.
Natural products, biochemistry, biosynthesis
|✔ Specialist skills||Intercultural skills||Communication skills||Critical thinking skills||Practical and/or problem-solving skills|
|Course schedule||Required learning|
|Class 1||Common mechanisms in biological chemistry||Understanding of common mechanisms in biological chemistry|
|Class 2||Biomolecules: lipids, carbohydrates, amino acids, proteins, nucleic acids||Understanding of lipids, carbohydrates, amino acids, proteins, nucleic acids|
|Class 3||Lipid metabolism 1: Triacylglycerol catabolism and fatty acid biosynthesis||Understanding of triacylglycerol catabolism and fatty acid biosynthesis|
|Class 4||Lipid metabolism 2: Terpenoid biosynthesis (mevalonate pathway and methylerythritol phosphate (MEP) pathway||Understanding of terpenoid biosynthesis (mevalonate pathway and methylerythritol phosphate (MEP) pathway|
|Class 5||Lipid metabolism 3: Steroid biosynthesis||Understanding of steroid biosynthesis|
|Class 6||Carbohydrate metabolism 1: Glycolysis||Understanding of glycolysis|
|Class 7||Carbohydrate metabolism 2: TCA cycle (citric acid cycle)||Understanding of fatty acid biosynthesis from acetyl CoA|
|Class 8||Amino acid metabolism 1: Deamination of amino acids and urea cycle||Understanding of deamination of amino acids and urea cycle|
|Class 9||Amino acid metabolism 2: Catabolism of amino acids||Understanding of catabolism of amino acids|
|Class 10||Amino acid metabolism 3: Biosynthesis of nonessential amino acids||Understanding of biosynthesis of nonessential amino acids|
|Class 11||Amino acid metabolism 4: Biosynthesis of essential amino acids||Understanding of biosynthesis of essential amino acids|
|Class 12||Biosynthesis of non-ribosomal peptides||Understanding of biosynthesis of non-ribosomal peptides|
|Class 13||Biosynthesis of alkaloids||Understanding of biosynthesis of alkaloids|
|Class 14||Biosynthesis of fatty acid derived compounds, polyketides, and coenzymes||Understanding of biosynthesis of fatty acid derived compounds, polyketides, and coenzymes|
To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.
The Organic Chemistry of Biological Pathways by McMurry & Begley
An understanding of the fundamentals of organic chemistry is required for this course.