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2021　Natural Product Chemistry

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Academic unit or major
Undergraduate major in Chemistry
Instructor(s)
Eguchi Tadashi  Kudo Fumitaka 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Tue5-6(S611)  Fri5-6(S611)  
Group
-
Course number
CHM.D334
Credits
2
Academic year
2021
Offered quarter
2Q
Syllabus updated
2021/3/19
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

I　Natural products are relatively small molecules, produced mainly by plants and microorganisms, that have a long history of uses (and misuses) by people, e. g. poisons, antibiotics, perfumes, malodor ants, cosmetics, dietary supplements, etc.
II　This course will focus on the basis of the biosynthetic pathways that lead to these natural organic compounds.

Student learning outcomes

After successful completion of this course, students should be able to (1) understand the field of natural products chemistry;
(2) identify natural products and their probable biosynthetic pathways; (3) enhance their understanding of biological and biochemical sciences.

Keywords

Natural products, biochemistry, biosynthesis

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Lectures

Course schedule/Required learning

  Course schedule Required learning
Class 1 Common mechanisms in biological chemistry Understanding of common mechanisms in biological chemistry
Class 2 Biomolecules: lipids, carbohydrates, amino acids, proteins, nucleic acids Understanding of lipids, carbohydrates, amino acids, proteins, nucleic acids
Class 3 Lipid metabolism 1: Triacylglycerol catabolism and fatty acid biosynthesis Understanding of triacylglycerol catabolism and fatty acid biosynthesis
Class 4 Lipid metabolism 2: Terpenoid biosynthesis (mevalonate pathway and methylerythritol phosphate (MEP) pathway Understanding of terpenoid biosynthesis (mevalonate pathway and methylerythritol phosphate (MEP) pathway
Class 5 Lipid metabolism 3: Steroid biosynthesis Understanding of steroid biosynthesis
Class 6 Carbohydrate metabolism 1: Glycolysis Understanding of glycolysis
Class 7 Carbohydrate metabolism 2: TCA cycle (citric acid cycle) Understanding of fatty acid biosynthesis from acetyl CoA
Class 8 Amino acid metabolism 1: Deamination of amino acids and urea cycle Understanding of deamination of amino acids and urea cycle
Class 9 Amino acid metabolism 2: Catabolism of amino acids Understanding of catabolism of amino acids
Class 10 Amino acid metabolism 3: Biosynthesis of nonessential amino acids Understanding of biosynthesis of nonessential amino acids
Class 11 Amino acid metabolism 4: Biosynthesis of essential amino acids Understanding of biosynthesis of essential amino acids
Class 12 Biosynthesis of non-ribosomal peptides Understanding of biosynthesis of non-ribosomal peptides
Class 13 Biosynthesis of alkaloids Understanding of biosynthesis of alkaloids
Class 14 Biosynthesis of fatty acid derived compounds, polyketides, and coenzymes Understanding of biosynthesis of fatty acid derived compounds, polyketides, and coenzymes

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Prints

Reference books, course materials, etc.

The Organic Chemistry of Biological Pathways by McMurry & Begley

Assessment criteria and methods

Final Exam

Related courses

  • CHM.D201 ： Organic Chemistry I
  • CHM.D202 ： Organic Chemistry II
  • CHM.D301 ： Organic Chemistry III

Prerequisites (i.e., required knowledge, skills, courses, etc.)

An understanding of the fundamentals of organic chemistry is required for this course.

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