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2020　Natural Product Chemistry

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Academic unit or major
Undergraduate major in Chemistry
Instructor(s)
Eguchi Tadashi  Kudo Fumitaka 
Class Format
Lecture    (ZOOM)
Media-enhanced courses
Day/Period(Room No.)
Tue5-6(H135)  Fri5-6(H135)  
Group
-
Course number
CHM.D334
Credits
2
Academic year
2020
Offered quarter
2Q
Syllabus updated
2020/9/18
Lecture notes updated
-
Language used
Japanese
Access Index

Course description and aims

I　Natural products are relatively small molecules, produced mainly by plants and microorganisms, that have a long history of uses (and misuses) by people, e. g. poisons, antibiotics, perfumes, malodor ants, cosmetics, dietary supplements, etc.
II　This course will focus on the basis of the biosynthetic pathways that lead to these natural organic compounds.

Student learning outcomes

After successful completion of this course, students should be able to (1) understand the field of natural products chemistry;
(2) identify natural products and their probable biosynthetic pathways; (3) enhance their understanding of biological and biochemical sciences.

Keywords

Natural products, biochemistry, biosynthesis

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Lectures

Course schedule/Required learning

  Course schedule Required learning
Class 1 What is natural product? What is natural product?
Class 2 DNA, RNA, proteins, and central dogma. Understanding of DNA, RNA, proteins, and central dogma.
Class 3 Primary and secondary metabolisms Understanding of primary and secondary metabolisms
Class 4 Glycolysis (first and second steps) Understanding of glycolysis (first and second steps)
Class 5 Glycolysis (third step) Understanding of glycolysis (third step)
Class 6 TCA cycle Understanding of TCA cycle
Class 7 Fatty acid biosynthesis from acetyl CoA Understanding of fatty acid biosynthesis from acetyl CoA
Class 8 Fatty acid related compounds and polyketides. Understanding of fatty acid related compounds and polyketides.
Class 9 Isoprenoids (mevalonate pathway) Understanding of isoprenoids (mevalonate pathway)
Class 10 Isoprenoids (Non-mevalonate pathway) Understanding of isoprenoids (Non-mevalonate pathway)
Class 11 Terpenes and steroids. Understanding of terpenes and steroids.
Class 12 Aromatic amino acids (shikimate pathway) Understanding of aromatic amino acids (shikimate pathway)
Class 13 Alkaloids from shipmate pathway. Understanding of alkaloids from shikimate pathway.
Class 14 Phenylpropanoids (flavonoids). Understanding of phenylpropanoids (flavonoids).

Out-of-Class Study Time (Preparation and Review)

To enhance effective learning, students are encouraged to spend approximately 100 minutes preparing for class and another 100 minutes reviewing class content afterwards (including assignments) for each class.
They should do so by referring to textbooks and other course material.

Textbook(s)

Prints

Reference books, course materials, etc.

None

Assessment criteria and methods

Final Exam

Related courses

  • CHM.D201 ： Organic Chemistry I
  • CHM.D202 ： Organic Chemistry II
  • CHM.D301 ： Organic Chemistry III

Prerequisites (i.e., required knowledge, skills, courses, etc.)

An understanding of the fundamentals of organic chemistry is required for this course.

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