This is a continuation of Organic Chemistry III. This course focuses on multistep synthesis of organic compounds, particularly introducing synthetic approaches to natural products.
At the end of this course, students will be able to have an understanding of basic concept of retrosynthesis and to learn about various synthetic methodology en route to complex natural products.
organic chemistry
synthetic organic chemistry
natural product synthesis
✔ Specialist skills | Intercultural skills | Communication skills | Critical thinking skills | Practical and/or problem-solving skills |
Attendance is taken in every class.
Course schedule | Required learning | |
---|---|---|
Class 1 | History of organic synthesis and examples for chemical syntheses of complex molecules. | Exercise problems might be given in this class. |
Class 2 | Concept of retro synthetic analysis I: latent polarity | Exercise problems might be given in this class. |
Class 3 | Concept of retro synthetic analysis II: synthons | Exercise problems might be given in this class. |
Class 4 | Formation of multiple C-C bonds, Wittig reaction, elimination | Exercise problems might be given in this class. |
Class 5 | Formation of multiple C-C bonds, other methods | Exercise problems might be given in this class. |
Class 6 | Synthesis of polycyclic compound: cyclization | Exercise problems might be given in this class. |
Class 7 | Synthesis of polycyclic compound: annulation | Exercise problems might be given in this class. |
Class 8 | Exercise I: basic problems | Exercise problems might be given in this class. |
Class 9 | Synthesis of chiral compound I: use of chiral synthons | Exercise problems might be given in this class. |
Class 10 | Synthesis of chiral compound II: asymmetric reaction | Exercise problems might be given in this class. |
Class 11 | Synthesis of alkaloids I: general approach | Exercise problems might be given in this class. |
Class 12 | Synthesis of alkaloids II: construction of polycyclic skeleton | Exercise problems might be given in this class. |
Class 13 | Exercise II: application problems | Exercise problems might be given in this class. |
Class 14 | Synthesis of prostaglandins I: Corey lactone | Exercise problems might be given in this class. |
Class 15 | Synthesis of prostaglandins II: other approaches | Exercise problems might be given in this class. |
None required
None required
Students’ course scores are based on final exams (ca. 70%) and exercise problems (30%) and also attendance.
Students require basic knowledge of organic chemistry.