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2019　Biophysics I

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Academic unit or major
Graduate major in Physics
Instructor(s)
Hayashi Nobuhiro 
Class Format
Lecture     
Media-enhanced courses
Day/Period(Room No.)
Tue5-6(H104)  
Group
-
Course number
PHY.C452
Credits
1
Academic year
2019
Offered quarter
1Q
Syllabus updated
2019/3/22
Lecture notes updated
2019/5/19
Language used
English
Access Index

Course description and aims

Although the life is so complicated as to seem to be mysterious, the microscopic and molecular elementary processes consist of simple physical events. However, when those simple events run together and fuse into each other, not only the complexity will be raised, but also qualitatively different ‘physical phenomena’ will be generated. That is the essence of the life. Biophysics deals with the ultimate physical phenomena created by the nature in the eternal flow of time. In this course, novel pictures of life drawn by biophysics will be shown, and approaches to reveal the essence of the life by the biophysics will be summarized.

Student learning outcomes

Biophysics is an area of natural science to tackle the eternal problem of life and death by means of physics. In the twentieth century, owing to the rapid advance of modern physics and technology, observation of life activities has become molecular level. As a result the knowledge of life has been expanded the knowledge of life enormously. Will the humankind become able to completely understand life and conquer death? To start with a long journey to answer this question, the very basic knowledge will be provided in this course.

Keywords

Life Science, Biophysics, Molecular Biology

Competencies that will be developed

✔ Specialist skills Intercultural skills Communication skills Critical thinking skills Practical and/or problem-solving skills

Class flow

Lecture

Course schedule/Required learning

  Course schedule Required learning
Class 1 Introduction: Summary of biomolecules Introduction
Class 2 Principles of functional architecture of proteins Functional architecture of proteins
Class 3 Principles of functional architecture of nucleic acids Functional architecture of nucleic acids
Class 4 Phasing approaches to observe biomolecules: Circular dichroism (CD), Surface plasmon resonance (SPR), Mass spectrometry, Solution small angel X-ray/neutron scattering, Nuclear magnetic resonance (NMR) Circular dichroism (CD), Surface plasmon resonance (SPR), Mass spectrometry, Solution small angel X-ray/neutron scattering, Nuclear magnetic resonance (NMR)
Class 5 Surface plasmon resonance (SPR), Mass spectrometry, Solution small angel X-ray/neutron scattering, Nuclear magnetic resonance (NMR) Circular dichroism (CD), Surface plasmon resonance (SPR), Mass spectrometry, Solution small angel X-ray/neutron scattering, Nuclear magnetic resonance (NMR)
Class 6 Understanding of the life using biophysics 1(case studies): Molecular mechanism of signaling on bio-membrane micro-domain. Molecular mechanism of signaling on bio-membrane micro-domain.
Class 7 Understanding of the life using biophysics 2(case studies): Molecular mechanism of signaling on bio-membrane micro-domain. Molecular mechanism of signaling on bio-membrane micro-domain.

Textbook(s)

There are no prior conditions for taking the course.

Reference books, course materials, etc.

There are no prior conditions for taking the course.

Assessment criteria and methods

Attendance and Reports

Related courses

  • PHY.C343 ： Chemical Physics

Prerequisites (i.e., required knowledge, skills, courses, etc.)

There are no prior conditions for taking the course.

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