This lecture covers research and development in the fine organic chemicals including pharmaceuticals. Students are encouraged to discuss synthetic route strategy and design, giving reasons and rationale for choice of reagents, solvents, conditions, etc., and learn unexpected differences observed as processes are scaled up. Students also learn aspects which may be important including yield improvement, cost reduction, improvement in space-time yield, etc. with reaction conditions, choice of solvent, workup and product isolation, safety, and environmental considerations.
This lecture is aimed at students who have a basic grounding in organic chemistry and attempts to convey an understanding organic process research with special focus on the development and optimization of chemical reactions and processes and their transfer to a larger scale, via large laboratory and pilot plant operations, for manufacture.
development and optimization of chemical reactions and processes
synthetic route strategy and design
development and optimization of processes and their scale-up
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