Advanced Course of Bioorganic Engineering

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Mihara Hisakazu  Matsuda Tomoko 
Lecture2  Exercise0  Experiment0
Syllabus updated
Lecture notes updated
Fall Semester

Outline of lecture

In the first half of the lectures, basic and advanced research status of biocatalysis is to be learned. The latter half of the lectures is regarding chemical syntheses of biomolecules, DNA & peptide, and those applications in biotechnology. 縲

Purpose of lecture

The purpose of this class is, through deep understanding of the two specific areas of cutting-edge research, to foster the ability of thinking logically and creatively.

Plan of lecture

1.Introduction to Biotransformation
2.Novel Reaction Conditions for Biotransformation-1
-Biotransformation in Ionic Liquid
-Temperature Control of the Enantioselectivity
3.Novel Reaction Conditions for Biotransformation-2
-Photosynthetic Organisms-catalyzed Reactions
-Catalysis by Enzyme-Metal Combinations
4.Uncommon Kind of Biocatalytic Reaction-1
-Baeyer-Villiger Oxidation
5.Uncommon Kind of Biocatalytic Reaction-2
-Aldoxime-nitrile Pathway
-Addition of Hydrocyanic Acid to Carbonyl Compounds
6.Novel Compound Synthesized by Biotransformation-1
-Chiral Heteroatom-Containing Compounds
-Enzymatic Polymerization
-Naturally Occurring ホイ-D-Glucopyranosides
7.Use of Molecular Biology Technique to Find Novel Biocatalyst
-Alcohol Dehydrogenase-Catalyzed Reactions
8.Examination etc.
9.Chemical Synthesis of DNA (1)
10.Chemical Synthesis of DNA (2)
11.Application of Synthetic DNA
12.Chemical Synthesis of Peptide & Protein (1)
13.Chemical Synthesis of Peptide & Protein (2)
14.Application of Synthetic Peptide (1): Chemical Library, Amyloid Disease
15.Application of Synthetic Peptide (2): Biochips, Protein chip
16.Examination etc.

Textbook and reference

Lecture 1 窶 8: Future directions in biocatalysis, Editor: T. Matsuda, Elsevier, Amsterdam, 2007.

Related and/or prerequisite courses

It is desired to have knowledge of basic organic chemistry.


Attendance, report, presentation, and/or examination

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