In the first half of the lectures, basic and advanced research status of biocatalysis is to be learned. The latter half of the lectures is regarding chemical syntheses of biomolecules, DNA & peptide, and those applications in biotechnology. 縲
The purpose of this class is, through deep understanding of the two specific areas of cutting-edge research, to foster the ability of thinking logically and creatively.
1.Introduction to Biotransformation
2.Novel Reaction Conditions for Biotransformation-1
-Biotransformation in Ionic Liquid
-Temperature Control of the Enantioselectivity
3.Novel Reaction Conditions for Biotransformation-2
-Photosynthetic Organisms-catalyzed Reactions
-Catalysis by Enzyme-Metal Combinations
4.Uncommon Kind of Biocatalytic Reaction-1
-Carboxylation
-Baeyer-Villiger Oxidation
5.Uncommon Kind of Biocatalytic Reaction-2
-Aldoxime-nitrile Pathway
-Addition of Hydrocyanic Acid to Carbonyl Compounds
6.Novel Compound Synthesized by Biotransformation-1
-Chiral Heteroatom-Containing Compounds
-Enzymatic Polymerization
-Naturally Occurring ホイ-D-Glucopyranosides
7.Use of Molecular Biology Technique to Find Novel Biocatalyst
-Alcohol Dehydrogenase-Catalyzed Reactions
-Decarboxylation
8.Examination etc.
9.Chemical Synthesis of DNA (1)
10.Chemical Synthesis of DNA (2)
11.Application of Synthetic DNA
12.Chemical Synthesis of Peptide & Protein (1)
13.Chemical Synthesis of Peptide & Protein (2)
14.Application of Synthetic Peptide (1): Chemical Library, Amyloid Disease
15.Application of Synthetic Peptide (2): Biochips, Protein chip
16.Examination etc.
Lecture 1 窶 8: Future directions in biocatalysis, Editor: T. Matsuda, Elsevier, Amsterdam, 2007.
It is desired to have knowledge of basic organic chemistry.
Attendance, report, presentation, and/or examination