- 使用教室
- 火3-4(B224)
- 単位数
- 講義：2 演習：0 実験：0
- 講義コード
- 82003
- シラバス更新日
- 2010年10月4日
- 講義資料更新日
- 2010年9月20日
- 学期
- 後期
講義概要
タンパク質，核酸，酵素，抗体などの生体高分子の基礎としてのその構造，機能発現の相関，分子の化学進化などと，チップテクノロジーなどへの工学応用や創薬応用への基礎について最近の話題を交えて述べる。
講義の目的
In the lecture 1-7, basic and advanced research status of biocatalysis is to be learned. The lecture 8-14 is regarding chemical syntheses of biomolecules, DNA & Peptide, and those applications in biotechnology.
講義計画
1. Introduction to Biotransformation
2. Novel Reaction Conditions for Biotransformation-1
-Biotransformation in Ionic Liquid
-Temperature Control of the Enantioselectivity
3. Novel Reaction Conditions for Biotransformation-2
-Photosynthetic Organisms-catalyzed Reactions
-Catalysis by Enzyme-Metal Combinations
4. Uncommon Kind of Biocatalytic Reaction-1
-Carboxylation
-Baeyer-Villiger Oxidation
5. Uncommon Kind of Biocatalytic Reaction-2
-Aldoxime-nitrile Pathway
-Addition of Hydrocyanic Acid to Carbonyl Compounds
6. Novel Compound Synthesized by Biotransformation-1
-Chiral Heteroatom-Containing Compounds
-Enzymatic Polymerization
-Naturally Occurring β-D-Glucopyranosides
7. Use of Molecular Biology Technique to Find Novel Biocatalyst
-Alcohol Dehydrogenase-Catalyzed Reactions
-Decarboxylation
8. Chemical Synthesis of DNA (1)
9. Chemical Synthesis of DNA (2)
10. Application of Synthetic DNA
11. Chemical Synthesis of Peptide & Protein (1)
12. Chemical Synthesis of Peptide & Protein (2)
13. Application of Synthetic Peptide (1): Chemical Library, Amyloid Disease
14. Application of Synthetic Peptide (2): Biochips, Protein chip
15. Examination etc.
教科書・参考書等
Lecture 1 – 7: Future directions in biocatalysis, Editor: T. Matsuda, Elsevier, Amsterdam, 2007.
関連科目・履修の条件等
For lecture 1-7, it is desired to have knowledge of basic organic chemistry.
成績評価
Attendance, report, presentation, and/or examination
