Bioorganic Engineering

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Mihara Hisakazu  Matsuda Tomoko 
Lecture2  Exercise0  Experiment0
Syllabus updated
Lecture notes updated
Fall Semester

Outline of lecture


Purpose of lecture

In the lecture 1-7, basic and advanced research status of biocatalysis is to be learned. The lecture 8-14 is regarding chemical syntheses of biomolecules, DNA & Peptide, and those applications in biotechnology.

Plan of lecture

1. Introduction to Biotransformation
2. Novel Reaction Conditions for Biotransformation-1
-Biotransformation in Ionic Liquid
-Temperature Control of the Enantioselectivity
3. Novel Reaction Conditions for Biotransformation-2
-Photosynthetic Organisms-catalyzed Reactions
-Catalysis by Enzyme-Metal Combinations
4. Uncommon Kind of Biocatalytic Reaction-1
-Baeyer-Villiger Oxidation
5. Uncommon Kind of Biocatalytic Reaction-2
-Aldoxime-nitrile Pathway
-Addition of Hydrocyanic Acid to Carbonyl Compounds
6. Novel Compound Synthesized by Biotransformation-1
-Chiral Heteroatom-Containing Compounds
-Enzymatic Polymerization
-Naturally Occurring ホイ-D-Glucopyranosides
7. Use of Molecular Biology Technique to Find Novel Biocatalyst
-Alcohol Dehydrogenase-Catalyzed Reactions
8. Chemical Synthesis of DNA (1)
9. Chemical Synthesis of DNA (2)
10. Application of Synthetic DNA
11. Chemical Synthesis of Peptide & Protein (1)
12. Chemical Synthesis of Peptide & Protein (2)
13. Application of Synthetic Peptide (1): Chemical Library, Amyloid Disease
14. Application of Synthetic Peptide (2): Biochips, Protein chip
15. Examination etc.

Textbook and reference

Lecture 1 – 7: Future directions in biocatalysis, Editor: T. Matsuda, Elsevier, Amsterdam, 2007.

Related and/or prerequisite courses

For lecture 1-7, it is desired to have knowledge of basic organic chemistry.


Attendance, report, presentation, and/or examination

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