- Lecturer
- Mihara Hisakazu Matsuda Tomoko
- Place
- Tue3-4(B224)
- Credits
- Lecture2 Exercise0 Experiment0
- Code
- 82003
- Syllabus updated
- 2010/10/4
- Lecture notes updated
- 2010/9/20
- Semester
- Fall Semester
Outline of lecture
繧ｿ繝ｳ繝代け雉ｪｼ梧ｸ驟ｸｼ碁ｵ邏ｼ梧蒲菴薙↑縺ｩ縺ｮ逕滉ｽ馴ｫ伜蟄舌ｮ蝓ｺ遉弱→縺励※縺ｮ縺昴ｮ讒矩ｼ梧ｩ溯ｽ逋ｺ迴ｾ縺ｮ逶ｸ髢｢ｼ悟蟄舌ｮ蛹門ｭｦ騾ｲ蛹悶↑縺ｩ縺ｨｼ後メ繝繝励ユ繧ｯ繝弱Ο繧ｸ繝ｼ縺ｪ縺ｩ縺ｸ縺ｮ蟾･蟄ｦ蠢懃畑繧蜑ｵ阮ｬ蠢懃畑縺ｸ縺ｮ蝓ｺ遉弱↓縺､縺縺ｦ譛霑代ｮ隧ｱ鬘後ｒ莠､縺医※霑ｰ縺ｹ繧九
Purpose of lecture
In the lecture 1-7, basic and advanced research status of biocatalysis is to be learned. The lecture 8-14 is regarding chemical syntheses of biomolecules, DNA & Peptide, and those applications in biotechnology.
Plan of lecture
1. Introduction to Biotransformation
2. Novel Reaction Conditions for Biotransformation-1
-Biotransformation in Ionic Liquid
-Temperature Control of the Enantioselectivity
3. Novel Reaction Conditions for Biotransformation-2
-Photosynthetic Organisms-catalyzed Reactions
-Catalysis by Enzyme-Metal Combinations
4. Uncommon Kind of Biocatalytic Reaction-1
-Carboxylation
-Baeyer-Villiger Oxidation
5. Uncommon Kind of Biocatalytic Reaction-2
-Aldoxime-nitrile Pathway
-Addition of Hydrocyanic Acid to Carbonyl Compounds
6. Novel Compound Synthesized by Biotransformation-1
-Chiral Heteroatom-Containing Compounds
-Enzymatic Polymerization
-Naturally Occurring ﾎｲ-D-Glucopyranosides
7. Use of Molecular Biology Technique to Find Novel Biocatalyst
-Alcohol Dehydrogenase-Catalyzed Reactions
-Decarboxylation
8. Chemical Synthesis of DNA (1)
9. Chemical Synthesis of DNA (2)
10. Application of Synthetic DNA
11. Chemical Synthesis of Peptide & Protein (1)
12. Chemical Synthesis of Peptide & Protein (2)
13. Application of Synthetic Peptide (1): Chemical Library, Amyloid Disease
14. Application of Synthetic Peptide (2): Biochips, Protein chip
15. Examination etc.
Textbook and reference
Lecture 1 – 7: Future directions in biocatalysis, Editor: T. Matsuda, Elsevier, Amsterdam, 2007.
Related and/or prerequisite courses
For lecture 1-7, it is desired to have knowledge of basic organic chemistry.
Evaluation
Attendance, report, presentation, and/or examination
