- Lecturer
- Komada Masayuki
- Place
- Fri5-6(B221)
- Credits
- Lecture2 Exercise0 Experiment0
- Code
- 81002
- Syllabus updated
- 2010/3/22
- Lecture notes updated
- 2010/3/22
- Semester
- Spring Semester
Outline of lecture
Outline of lecture:
For normal cellular activities, proteins need to be transported correctly to the subcellular compartment or extracellular space where they exert function. Membrane traffic is a major mechanism that facilitates protein transport between membrane-bound organelles in eukaryotic cells. This course focuses on the molecular mechanisms as well as physiological and pathological roles of various intracellular membrane traffic processes. Equal efforts will be made to address the fundamentals and recent progress on each subject.
Purpose of lecture
Purpose of lecture:
The aim of this lecture is to understand how the membrane traffic processes allow precise transport of proteins and other biomolecules to different compartments in the cell, what the biological significance of the processes are, and what the pathological consequences caused by dysregulation of the processes are.
Plan of lecture
Plan of lecture:
1. Endocytosis (membrane deformation)
2. Endocytic pathway (traffic from cell surface to lysosomes)
3. Budding of enveloped viruses from host cells
4. Viral strategy to evade host defense system (traffic of MHC class I)
5. Secretory pathway (traffic from endoplasmic reticulum to cell surface)
6. Traffic from the Golgi to endosomes
7. Exocytosis (membrane fusion)
8. Rab family of small GTPases
9. Autophagy - molecular mechanisms
10. Autophagy - physiological roles
11. Kinesin-mediated vesicle transport
Textbook and reference
Textbook and/or reference:
none
Related and/or prerequisite courses
Related subject and/or stipulation:
none
Evaluation
Evaluation:
tests, report
Comments from lecturer
teacher in charge (Comment by Option):
Supplement
Other (Option):
