細胞生化学特論   Advanced Cell Biochemistry

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担当教員
駒田 雅之 
使用教室
 
単位数
講義:2  演習:0  実験:0
講義コード
81002
シラバス更新日
2009年7月30日
講義資料更新日
2009年7月30日
学期
前期

講義概要

Outline of lecture:
For normal cellular activities, proteins need to be transported correctly to the subcellular compartment or extracellular space where they exert function. Membrane traffic is a major mechanism that facilitates protein transport between membrane-bound organelles in eukaryotic cells. This course focuses on the molecular mechanisms as well as physiological and pathological roles of various intracellular membrane traffic processes. Equal efforts will be made to address the fundamentals and recent progress on each subject.

講義の目的

Purpose of lecture:
The aim of this lecture is to understand how the membrane traffic processes allow precise transport of proteins and other biomolecules to different compartments in the cell, what the biological significance of the processes are, and what the pathological consequences caused by dysregulation of the processes are.

講義計画

Plan of lecture:
1. Endocytosis (membrane deformation)
2. Endocytic pathway (traffic from cell surface to lysosomes)
3. Budding of enveloped viruses from host cells
4. Viral strategy to evade host defense system (traffic of MHC class I)
5. Secretory pathway (traffic from endoplasmic reticulum to cell surface)
6. Traffic from the Golgi to endosomes
7. Exocytosis (membrane fusion)
8. Rab family of small GTPases
9. Autophagy - molecular mechanisms
10. Autophagy - physiological roles
11. Kinesin-mediated vesicle transport

教科書・参考書等

Textbook and/or reference:
none

関連科目・履修の条件等

Related subject and/or stipulation:
none

成績評価

Evaluation:
tests, report

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teacher in charge (Comment by Option):

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