Creation of bioactive organic compounds, including chemical modifications, will be discussed. This lecture is held in English.
逕滉ス鍋黄雉ェ縺ョ蛹門ュヲ菫ョ鬟セ繧貞性繧√※シ檎函逅讖溯ス繧呈怏縺吶k譛画ゥ溷喧蜷育黄縺ョ蜑オ陬ス縺ォ縺、縺縺ヲ隗」隱ャ縺吶k縲りャ帷セゥ縺ッ闍ア隱槭〒陦後o繧後k縲
Creation of bioactive organic compounds, including chemical modifications, will be discussed. This lecture is held in English.
Organic synthesis is one of the most powerful tools to create drugs for diseases, such as cancer, diabetes, flu, and etc. Thus the knowledge and skills of organic synthesis are prerequisite for theresearch in pharmaceutical industry. The aim of this class is to have you understand the logics and mechanisms underlying the design and synthesis of bioactive molecules. To make the class less bored, each lecture will deal with the synthesis of a few compounds, with which the basic principles behind the constituent reactions will be uncovered. Therefore, you do not have to attend all of the classes. The first half of this class will be based on the text book, 窶弋op Drugs: Top Synthetic Routes窶(John Saunders, Oxford University Press: Oxford, 2000). Our own research results are discussed in the latter half.
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
Inhibitors of angiotensin converting enzyme
Blockade of angiotensin-II receptors
Calcium channel blockers
Antagonists of histamine receptors
Proton pump inhibitors
Modulation of central serotonin
Ligands for benzodiazepine receptor
Blockers of the H1 recptor
Inhibitors of HIV reverse transcriptase
Anti-bacterial DNA gyrase inhibitors
Glycosidase inhibitors against diabetes
Carbohydrate-based future drugs
Principles of mimics and mimetics
Dynamic molecules for future drugs
Peptide synthesis (optional)
驟榊ク雉譁咏ュ
蜃コ蟶ュシ梧シ皮ソ抵シ後Ξ繝昴シ繝医r邱丞粋縺励※隧穂セ。縺吶k縲
Attendance and report